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KMID : 0352719940180030165
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Journal of Ginseng Research
1994 Volume.18 No. 3 p.165 ~ p.174
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The Central Effects of Saponin Components and Polysaccarides Fraction from Korean Red Ginseng
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Abstract
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To investigate the significant indicators improving the undisturbed memory in animal behavior, we employed several behavioral methods (learning, relearning in radial maze, and active avoidance) with ginseng components. Results showed that the
repeated
intranasal administration of Rb1 and total saponins from Korean red ginseng induced direct effects on the brain mechanisms in rats, and improved the spatial memory during the learning. Relearning and retention in the 12-arm radial maze test. The
intranasal treatment of the total saponins also effectively improved the disturbed memory (amnesia) by pentylentetrazole, and simultaneously protected the brain by decreasing the severity of motor epileptic seizures. The intraperitonial
administration
of polysaccharide fraction of Korean red ginseng could improve avoidance behavior (amount of the total ecapes) in the active-avoidance test. In addition, local changes of the temperature and resistance of skin observed after Rb1 administration
were
suggested to reflect some action of sympathetic nerve.
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